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I am female, 41, have been taking methotrexate for 2 months now. I was crippled, my hands fingers wrists ankles balls of my feet knees shoulders arms even my jaw. I could barely walk I couldn't unscrew lids, peel potatoes, do everyday chores people take for granted. My rheumatoid factor was 1380. After 1 month no change hopefully my 2nd reading it will come down. Anyway after 1 month on the medication my joint pains has disappeared thanks to Methotrexate. I take 10mg once weekly with folic acid next day. Worked for me. YAY!
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I use methotrexate to treat my rheumatoid arthritis and I'm absolutely ok with the quality and effectiveness of the drug. I've been taking Methotrexate since 2009. My side effects are minimal. Once a week I may have nausea or slight migraine, but nothing more serious. My tests results have come back normal. Diclofenac helps with my rheumatoid arthritis a lot.

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Folic and folinic acid also appear to be protective against abnormal serum transaminase elevation caused by MTX, with a 76.

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