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The study also demonstrated that gene amplification and protein overexpression (IHC) are not as correlated as with breast cancer, therefore a single method should not be used to determine HER2 status.
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Additive antitumor effects of the epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib (Iressa), and the nonsteroidal antiandrogen, bicalutamide (Casodex), in prostate cancer cells in vitro.
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Although plasma and tumor concentrations of M537194 were low, this metabolite seemed to distribute preferentially into tumor tissue in a manner similar to gefitinib.
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Tarceva (erlotinib) as a non-chemotherapy “wild card”; people rarely do better with later lines of chemotherapy than they did in the first line setting.
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By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs).
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Iodine I 131 monoclonal antibody CC49 delivers beta and gamma radiation-emitting I 131 radionuclide specifically to tumor cells that express tumor-associated glycoprotein (TAG)-72, allowing localization of TAG-72-expressing tumor cells with radioimaging devices in diagnostic applications or resulting in specific TAG-72-expressing tumor cell radiocytotoxicity in therapeutic applications.
Erasmus Medical Centre in the Netherlands is one of Europe's largest hyperthermia centres.
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Bristol-Myers Squibb, Genentech, and Xcovery; she reported serving on a scientific advisory board, as a consultant, or expert witness for Bayer HealthCare, Bristol-Myers Squibb, Lilly, Genentech, Merck, and Xcovery.
All narrative on growth and results in this section relates to Core performance, based on constant exchange rates (CER) unless stated otherwise.
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In this case, the FDA approved the use of gefitinib specifically for those NSCLC patients who have metastatic cancer, who have not received any treatment, and whose cancers have the most common types of EGFR mutation: exon 19 deletions or exon 21 L858R substitution gene mutations.
Moreover, the mice are especially sensitive to the carcinogenic effects of tobacco smoke.
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Phase 3 study failed to show the drug significantly prolonged survival and it was pulled from the market in June 2005.
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This means that although a drug may be funded for one type of cancer, at a particular stage, funding may not be available for the same cancer at a different stage or for another type of cancer.
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Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your treatment ends.
SCH-772984 effectively inhibits MAPK signaling and cell proliferation in BRAF or MEK inhibitor resistant models.
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Stewart W, Lauret P, Testart J, Thomine E, Boulliê M, Leroy D (1977).
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In an exam this afternoon, March 19, 2013 (1 year later), it appeared that the GGO has changed, in that it was a little larger and was more “dense”, but not “solid”.
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