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Although generally well-tolerated, the following adverse reactions were reported in the first phase of WHO-coordinated studies1 involving 30 patients given high-dose therapy with albendazole for the treatment of cystic echinococcosis (hydatid disease): raised serum-transaminase levels (2 patients), reduced leucocyte counts (1 patient), gastrointestinal symptoms (1 patient), allergic conditions (1 patient), and loss of hair (1 patient).
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In this review, as we stated in 2003, 2007, and 2012, we have yet again demonstrated that natural products play a dominant role in the discovery of leads for the development of drugs for the treatment of human diseases.
In 77 patients with light necatoriasis (Necator americanus infection) albendazole, in a single 400-mg dose, produced an 84% cure rate and an 82% reduction in egg count in those patients not cured.
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How should these concepts be integrated practically into the drug discovery process.
The extensive data sets shown in the figures and tables referred to above continue to highlight the continuing role that natural products and structures derived from or related to natural products from all sources have played, and continue to play, in the development of the current therapeutic armamentarium of the physician.
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In the case of all approved therapeutic agents, the time frame has been extended to cover the 34 years from January 1, 1981, to December 31, 2014, for all diseases worldwide, and from 1950 (earliest so far identified) to December 2014 for all approved antitumor drugs worldwide.
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